PAPERS論文

総説

• Therapeutic Angiogenesis with Sound Waves

  Shindo T, and Shimokawa H

  Ann Vasc Dis. 2020;13(2):116–125.

  http://www.cardio.med.tohoku.ac.jp/pdf/13_ra.20-00010.pdf

低出力体外衝撃波治療

• Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

  狭心症：基礎研究論文

  Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, Matsumoto Y, Kajihara N, Eto M, Matsuda T, Yasui h, Takeshita A, and Sunagawa K

  Circulation 2004;110(19):3055-3061.

  https://www.ahajournals.org/doi/10.1161/01.CIR.0000148849.51177.97

• Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.

  狭心症：基礎研究論文

  Fukumoto Y, Ito A, Uwatoku T, Matoba T, Kishi T, Tanaka H, Takeshita A, Sunagawa K, Shimokawa H.

  Coron Artery Dis. 2006;17:63-70.

  https://pubmed.ncbi.nlm.nih.gov/16374144/

• Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs

  心筋梗塞：基礎研究論文１

  Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K and Shimokawa H

  Coron Artery Dis. 2007;18(5):397-404.

  https://journals.lww.com/coronary-artery/Abstract/2007/08000/Extracorporeal_cardiac_shock_wave_therapy_improves.11.aspx

• Extracorporeal Shock Wave Therapy Ameliorates Hindlimb Ischemia in Rabbits

  下肢閉塞性動脈硬化症：基礎研究論文

  Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T and Shimokawa H

  Tohoku J. Exp. Med. 2008;214(2):151-158.

  https://www.jstage.jst.go.jp/article/tjem/214/2/214_2_151/_article

• Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris

  狭心症：臨床研究論文２：RCT試験

  Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I and Shimokawa H

  Circ J 2010;74(3):589-591.

  https://www.jstage.jst.go.jp/article/circj/74/3/74_CJ-09-1028/_article

• Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia–reperfusion injury in pigs in vivo

  心筋梗塞：基礎研究論文２

  Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi Gao Jun, Takeda M, Fukumoto Y, Yasuda S and Shimokawa H

  Coron Artery Dis. 2010;21(5):304-311.

  https://journals.lww.com/coronary-artery/Abstract/2010/08000/Cardiac_shock_wave_therapy_ameliorates_left.9.aspx

• Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema

  リンパ浮腫：基礎研究論文

  Serizawa F, Ito K, Matsubara M, Sato A, Shimokawa H and Satomi S

  Eur J Vasc Endovasc Surg 2011;42(2):254-260.

  https://www.sciencedirect.com/science/article/pii/S1078588411001328?via%3Dihub

• Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication

  下肢閉塞性動脈硬化症：臨床研究論文

  Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato a, Shimokawa H and Satomi S

  Circ J. 2012;76(6):1486-1493.

  https://www.jstage.jst.go.jp/article/circj/76/6/76_CJ-11-1216/_article

• Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury

  脊髄損傷：基礎研究論文

  Yamaya S, Ozawa H, Kanno H, Kishimoto K, Sekiguchi A, Tateda S, Yahata K, Ito K, Shimokawa H and Itoi E

  J. Neurosurg. 2014;121(6):1514–1525.

  https://thejns.org/view/journals/j-neurosurg/121/6/article-p1514.xml

• Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

  膠原病性手指潰瘍：臨床研究論文

  Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y and Harigae H

  Tohoku J. Exp. Med. 2016;238(1):39-47.

  https://www.jstage.jst.go.jp/article/tjem/238/1/238_39/_article

• Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction

  低出力体外衝撃波の作用機序：基礎研究論文

  Hatanaka K, Ito K, Shindo T, Kagaya Y, Ogata T, Eguchi K, Kurosawa R and Shimokawa H

  Am J Physiol Cell Physiol 2016;311(3):C378-C385.

  https://journals.physiology.org/doi/full/10.1152/ajpcell.00152.2016

• Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: a first-in-human study

  心筋梗塞：臨床研究論文

  Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Shiroto T, Tsuburaya R, Kikuchi Y, Hao K, Nishimiya K, Shindo T, Ogata T, Kurosawa R, Eguchi K, Monma Y, Ichijo S, Hatanaka K, Miyata S and Shimokawa H.

  Coron Artery Dis. 2018;29(4):294-300.

  https://journals.lww.com/coronary-artery/Abstract/2018/06000/Low_energy_cardiac_shockwave_therapy_to_suppress.4.aspx

LIPUS：狭心症

• Low-Intensity Pulsed Ultrasound Induces Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Porcine Model of Chronic Myocardial Ischemia

  狭心症：基礎研究論文

  Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, Tuburaya R, Hasegawa H, Yasuda S, Kanai H and Shimokawa H

  PLOS ONE 2014;9(8): e104863.

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104863

• Low-Intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Mouse Model of Acute Myocardial Infarction

  心筋梗塞：基礎研究論文

  Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, Kagaya Y, Hanawa K, Aizawa K, Shiroto T, Kasukabe S, Miyata S, Taki H, Hasegawa H, Kanai H and Shimokawa H

  Arterioscler. Thromb. Vasc. Biol. 2016;36(6):1220-1229.

  https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306477

• Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

  圧負荷心不全：基礎研究論文

  Ogata T, Ito K, Shindo T, Hatanaka K, Eguchi K, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Taki H, Kanai H and Shimokawa H

  PLOS ONE 2017;12(9):e0185555.

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185555

• Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo.

  Watanabe T, Matsumoto Y, Nishimiya K, Shindo T, Amamizu H, Sugisawa J, Tsuchiya S, Sato K, Morosawa S, Ohyama K, Watanabe-Asaka T, Hayashi M, Kawai Y, Takahashi J, Yasuda S and Shimokawa H

  PLOS ONE 2021;16(9):e0257175.

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257175

• A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris

  重症狭心症：医師主導探索的治験

  Shindo T,Ito K,Ogata T,Kurosawa R,Eguchi K,Kagaya Y,Hanawa K,Hasebe Y,Nishimiya K,Shiroto T,Takahashi J,Okumura Y,Noguchi T,Ozaki Y,Daida H,Hagiwara N,Masuyama T,Chikamori T,Fukumoto Y,Tsujita K,Kanai H,Yasuda S,Shimokawa H

  PLOS ONE June 23, 2023;doi.org/10.1371/journal.pone.0287714

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287714

LIPUS：心不全、肺高血圧症

• Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction

  Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H and Shimokawa H

  Cardiovasc. Res. 2017;117(5):1325-1338.

  https://academic.oup.com/cardiovascres/article/117/5/1325/5873597

• Beneficial effects of low-intensity pulsed ultrasound therapy on right ventricular dysfunction in animal models.

  心不全、肺高血圧症1

  Nakata T, Shindo T, Ito K, Eguchi K, Monma Y, Ichijo S, Ryoke R, Satoh W, Kumasaka K, Satoh H, Kurosawa R, Satoh K, Kawashima R, Miura M, Kanai H, Yasuda S, Shimokawa H.

  JACC: Basic to Translational Science (in press) 2017;117(5):1325-1338.

  https://www.sciencedirect.com/science/article/pii/S2452302X22003382

LIPUS：認知症

• Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia – Crucial roles of endothelial nitric oxide synthase

  認知症：基礎研究論文1

  Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N and Shimokawa h

  Brain Stim 2018;11(5):959-973.

  https://www.sciencedirect.com/science/article/pii/S1935861X18301591?via%3Dihub

• Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo. 

  認知症：基礎研究論文2

  Ichijo S, Shindo T, Eguchi K, Monma Y, Nakata T, Morisue Y, Kanai H, Osumi N, Yasuda S and Shimokawa H

  Sci. Rep. 2021;11(4958).

  https://www.nature.com/articles/s41598-021-84473-6

• Optimizing irradiation conditions for low‑intensity pulsed ultrasound to upregulate endothelial nitric oxide synthase 

  認知症：基礎研究論文3

  Ouchi D, Mori S, Arakawa M, Shindo T, Shimokawa H, Yasuda S, Kanai H

  Journal of Medical Ultrasonics. (2024) 51:39–48.

  https://link.springer.com/article/10.1007/s10396-023-01382-z

• Optimal treatment conditions of the low-intensity pulsed ultrasound therapy for the　treatment of Alzheimer’s disease -Applications from mice to humans-  

  認知症：基礎研究論文4

  Shindo T, Eguchi K, Monma Y, Kanai H, Yasuda S, Shimokawa H.

  J Med Ultrasonics. (in press).

• A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial 

  認知症：臨床研究論文1

  Shimokawa H, Shindo T, Ishiki A, Tomita N, Ichijyo S, Watanabe T, Nakata T, Eguchi K, Kikuchi Y, Shiroto T, Takahashi J, Yasuda S, Arai　H

  Tohoku J. Exp. Med. 2022, 258, 167-W17h5.

  https://www.jstage.jst.go.jp/article/tjem/258/3/258_2022.J078/_article

衝撃波アブレーションカテーテル

• Development of a Novel Shock Wave Catheter Ablation System -The First Feasibility Study in Pigs-

  基礎研究論文１(システム開発）

  Hasebe Y, Yamamoto H, Fukuda K, Nishimiya K, Hanawa K, Shindo T, Kondo M, Nakano M, Wakayama Y, Takayama K and Shimokawa H

  PLOS ONE 2014;10(1):e0116017.

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116017

• Development of a novel shock wave catheter ablation system—A validation study in pigs in vivo

  基礎研究論文２（Validation研究１）

  Hirano M, Yamamoto H, Hasebe Y, Fukuda K, Morosawa S, Amamizu H, Ohyama K, Uzuka H, Takayama K and Shimokawa H

  Europace 2018;20(11):1856-1865.

  https://academic.oup.com/europace/article/20/11/1856/4060663

• Development of a Shock-Wave Catheter Ablation System for Ventricular Tachyarrhythmias: Validation Study in Pigs In Vivo

  基礎研究論文３（Validation研究２）

  Morosawa S, Yamamoto H, Hirano M, Amamizu H, Uzuka H, Ohyama K, Hasebe Y, Nakano M, Fukuda K, Takayama K and Shimokawa H

  J. Am. Heart Assoc. 2019;8(2):e011038.

  https://www.ahajournals.org/doi/10.1161/JAHA.118.011038