Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia – Crucial roles of endothelial nitric oxide synthase
Dementia: Basic research paper
Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N and Shimokawa h
Optimal treatment conditions of the low-intensity pulsed ultrasound therapy for the treatment of Alzheimer’s disease -Applications from mice to humans-
Dementia: Basic research paper
Shindo T, Eguchi K, Monma Y, Kanai H, Yasuda S, Shimokawa H.
A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial
Dementia： clinical research paper
Shimokawa H, Shindo T, Ishiki A, Tomita N, Ichijyo S, Watanabe T, Nakata T, Eguchi K, Kikuchi Y, Shiroto T, Takahashi J, Yasuda S, Arai H
Baseline characteristics of patients with early Alzheimer’s disease enrolled in the pivotal trial of low-intensity pulsed ultrasound (LIPUS-AD)
Dementia： clinical research paper 3
Shimokawa H, Akishita M, Asada T, Katayama S, Hattori Y, Yakushiji Y, Taki Y, Murai H, Boku Y, Tsujimoto M, Umegaki H, Ogawa T, Matsumoto S, Ono K, Imon Y, Tsunemi T, Iwata A, Hanajima R, Hisahara S, Uehara T, Ishiguro T, Nakaoku Y, Ishii K, Ishiki A,i Nagai Y, Teramukai S, Ihara M, Fukukushima M
Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo.
Watanabe T, Matsumoto Y, Nishimiya K, Shindo T, Amamizu H, Sugisawa J, Tsuchiya S, Sato K, Morosawa S, Ohyama K, Watanabe-Asaka T, Hayashi M, Kawai Y, Takahashi J, Yasuda S and Shimokawa H
Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris
Angina: Clinical Research Paper 2: RCT Study
Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I and Shimokawa H
Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction:a first-in-human study
Myocardial infarction: clinical research paper
Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Shiroto T, Tsuburaya R, Kikuchi Y, Hao K, Nishimiya K, Shindo T, Ogata T, Kurosawa R, Eguchi K, Monma Y, Ichijo S, Hatanaka K, Miyata S and Shimokawa H.
Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication
Arteriosclerosis obliterans of the lower extremities: Clinical research paper
Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato a, Shimokawa H and Satomi S
Effectiveness and safety of low-energy shock wave therapy for digital ulcers associated with systemic sclerosis: a phase 3 pivotal clinical trial.
Collagen Disease: Clinical Research Papers
Ishii T, Kawaguchi Y, Ishikawa O, Takemori H, Takasawa N, Kobayashi H, Takahashi Y, Yasuoka H, Kodera T, Takai O, Nakaya I, Sato Y, Izumiyama T, Fujii H, Kamogawa Y, Shirota Y, Shirai T, Fujita Y, Saito S, Chiu SW, Yamaguchi T, Shimokawa H, Harigae H..
doi: 10.1093/mr/roae104. Online ahead of print.PMID: 39562303
Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury.
Spinal Cord Injury: A Basic Research Paper
Yahata K, Kanno H, Ozawa H, Yamaya S, Tateda S, Ito K, Shimokawa H, Itoi E.
Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction
Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H, Shimokawa H.
