Papers

Review

• Therapeutic Angiogenesis with Sound Waves

  Shindo T, and Shimokawa H

  http://www.cardio.med.tohoku.ac.jp/pdf/13_ra.20-00010.pdf

  read this paper

• Therapeutic potentials of sound waves in cardiovascular medicine: further important evidence

  Shimokawa H

  https://doi.org/10.1093/eurheartj/ehae253

  read this paper

LIPUS: Angina

• Low-Intensity Pulsed Ultrasound Induces Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Porcine Model of Chronic Myocardial Ischemia

  Angina: Basic research paper

  Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, Tuburaya R, Hasegawa H, Yasuda S, Kanai H and Shimokawa H

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104863

  read this paper

• Low-Intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Mouse Model of Acute Myocardial Infarction

  Myocardial infarction: Basic research paper

  Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, Kagaya Y, Hanawa K, Aizawa K, Shiroto T, Kasukabe S, Miyata S, Taki H, Hasegawa H, Kanai H and Shimokawa H

  https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306477

  read this paper

• Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

  Pressure-loaded heart failure: Basic research paper

  Ogata T, Ito K, Shindo T, Hatanaka K, Eguchi K, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Taki H, Kanai H and Shimokawa H

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185555

  read this paper

• Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo.

  Watanabe T, Matsumoto Y, Nishimiya K, Shindo T, Amamizu H, Sugisawa J, Tsuchiya S, Sato K, Morosawa S, Ohyama K, Watanabe-Asaka T, Hayashi M, Kawai Y, Takahashi J, Yasuda S and Shimokawa H

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257175

  read this paper

• A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris

  Severe Angina : Feasibility Clinical Trial

  Shindo T,Ito K,Ogata T,Kurosawa R,Eguchi K,Kagaya Y,Hanawa K,Hasebe Y,Nishimiya K,Shiroto T,Takahashi J,Okumura Y,Noguchi T,Ozaki Y,Daida H,Hagiwara N,Masuyama T,Chikamori T,Fukumoto Y,Tsujita K,Kanai H,Yasuda S,Shimokawa H

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287714

  read this paper

Low power extracorporeal shock wave treatment

• Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

  Angina: Basic research paper

  Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, Matsumoto Y, Kajihara N, Eto M, Matsuda T, Yasui h, Takeshita A, and Sunagawa K

  https://www.ahajournals.org/doi/10.1161/01.CIR.0000148849.51177.97

  read this paper

• Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.

  Angina: Basic research paper

  Fukumoto Y, Ito A, Uwatoku T, Matoba T, Kishi T, Tanaka H, Takeshita A, Sunagawa K, Shimokawa H.

  https://pubmed.ncbi.nlm.nih.gov/16374144/

  read this paper

• Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris

  Angina: Clinical Research Paper 2: RCT Study

  Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I and Shimokawa H

  https://www.jstage.jst.go.jp/article/circj/74/3/74_CJ-09-1028/_article

  read this paper

• Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs

  Myocardial infarction: Basic research paper 1

  Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K and Shimokawa H

  https://journals.lww.com/coronary-artery/Abstract/2007/08000/Extracorporeal_cardiac_shock_wave_therapy_improves.11.aspx

  read this paper

• Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia–reperfusion injury in pigs in vivo

  Myocardial infarction: Basic research paper 2

  Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi Gao Jun, Takeda M, Fukumoto Y, Yasuda S and Shimokawa H

  https://journals.lww.com/coronary-artery/Abstract/2010/08000/Cardiac_shock_wave_therapy_ameliorates_left.9.aspx

  read this paper

• Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction:a first-in-human study

  Myocardial infarction: clinical research paper

  Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Shiroto T, Tsuburaya R, Kikuchi Y, Hao K, Nishimiya K, Shindo T, Ogata T, Kurosawa R, Eguchi K, Monma Y, Ichijo S, Hatanaka K, Miyata S and Shimokawa H.

  https://journals.lww.com/coronary-artery/Abstract/2018/06000/Low_energy_cardiac_shockwave_therapy_to_suppress.4.aspx

  read this paper

• Extracorporeal Shock Wave Therapy Ameliorates Hindlimb Ischemia in Rabbits

  Arteriosclerosis obliterans of the lower extremities: Clinical research paper

  Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T and Shimokawa H

  https://www.jstage.jst.go.jp/article/tjem/214/2/214_2_151/_article

  read this paper

• Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication

  Arteriosclerosis obliterans of the lower extremities: Clinical research paper

  Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato a, Shimokawa H and Satomi S

  https://www.jstage.jst.go.jp/article/circj/76/6/76_CJ-11-1216/_article

  read this paper

• Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

  Collagen disease digital ulcers: clinical research paper

  Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y and Harigae H

  https://www.jstage.jst.go.jp/article/tjem/238/1/238_39/_article

  read this paper

• Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema

  Lymphedema: Basic research paper

  Serizawa F, Ito K, Matsubara M, Sato A, Shimokawa H and Satomi S

  https://www.sciencedirect.com/science/article/pii/S1078588411001328?via%3Dihub

  read this paper

• Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury

  Spinal cord injury: Basic research paper

  Yamaya S, Ozawa H, Kanno H, Kishimoto K, Sekiguchi A, Tateda S, Yahata K, Ito K, Shimokawa H and Itoi E

  https://thejns.org/view/journals/j-neurosurg/121/6/article-p1514.xml

  read this paper

• Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction.

  Mechanism of action of low-power extracorporeal shock waves: Basic research paper

  Hatanaka K, Ito K, Shindo T, Kagaya Y, Ogata T, Eguchi K, Kurosawa R and Shimokawa H

  https://journals.physiology.org/doi/full/10.1152/ajpcell.00152.2016/

  read this paper

• Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats.

  Kidney injury：Basic research paper

  Yoshida M, Nakamichi T, Mori T, Ito K, Shimokawa H, Ito S.

  https://pubmed.ncbi.nlm.nih.gov/30617840/

  read this paper

LIPUS: Heart failure

• Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction

  Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H, Shimokawa H.

  https://academic.oup.com/cardiovascres/article/117/5/1325/5873597

  read this paper

• Beneficial effects of low-intensity pulsed ultrasound therapy on right ventricular dysfunction in animal models.

  Nakata T, Shindo T, Ito K, Eguchi K, Monma Y, Ichijo S, Ryoke R, Satoh W, Kumasaka K, Satoh H, Kurosawa R, Satoh K, Kawashima R, Miura M, Kanai H, Yasuda S, Shimokawa H.

  https://www.sciencedirect.com/science/article/pii/S2452302X22003382

  read this paper

LIPUS: Dementia

• Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia – Crucial roles of endothelial nitric oxide synthase

  Dementia: Basic research paper

  Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N and Shimokawa h

  https://www.sciencedirect.com/science/article/pii/S1935861X18301591?via%3Dihub

  read this paper

• Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo. 

  Dementia: Basic research paper

  Ichijo S, Shindo T, Eguchi K, Monma Y, Nakata T, Morisue Y, Kanai H, Osumi N, Yasuda S, Shimokawa H.

  https://www.nature.com/articles/s41598-021-84473-6

  read this paper

• Optimizing irradiation conditions for low‑intensity pulsed ultrasound to upregulate endothelial nitric oxide synthase 

  Dementia: Basic research paper

  Ouchi D, Mori S, Arakawa M, Shindo T, Shimokawa H, Yasuda S, Kanai H

  https://link.springer.com/article/10.1007/s10396-023-01382-z

  read this paper

• Optimal treatment conditions of the low-intensity pulsed ultrasound therapy for the　treatment of Alzheimer’s disease -Applications from mice to humans- 

  Dementia: Basic research paper

  Shindo T, Eguchi K, Monma Y, Kanai H, Yasuda S, Shimokawa H.

  J Med Ultrasonics.

  read this paper

• A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial 

  Dementia： clinical research paper

  Shimokawa H, Shindo T, Ishiki A, Tomita N, Ichijyo S, Watanabe T, Nakata T, Eguchi K, Kikuchi Y, Shiroto T, Takahashi J, Yasuda S, Arai　H

  https://www.jstage.jst.go.jp/article/tjem/258/3/258_2022.J078/_article

  read this paper

• Pivotal trial of low-intensity pulsed ultrasound therapy for early Alzheimer’s disease -Rationale and design- 

  Dementia： clinical research paper 2

  Shimokawa H, Akishita M, Ihara M, Teramukai S, Ishiki A, Nagai Y, Fukushima M.

  (in press)

Shock wave ablation catheter

• Development of a Novel Shock WaveCatheter Ablation System -The First Feasibility Study in Pigs

  Basic Research Paper 1 (System Development)

  Hasebe Y, Yamamoto H, Fukuda K, Nishimiya K, Hanawa K, Shindo T, Kondo M, Nakano M, Wakayama Y, Takayama K and Shimokawa H

  http://www.cardio.med.tohoku.ac.jp/class/pdf/originalpapers_2015_03.pdf

  read this paper

• Development of a novel shock wave catheter ablation system—A validation study in pigs in vivo

  Basic Research Paper 2 (Validation Research 1)

  Hirano M, Yamamoto H, Hasebe Y, Fukuda K, Morosawa S, Amamizu H, Ohyama K, Uzuka H, Takayama K and Shimokawa H

  http://www.cardio.med.tohoku.ac.jp/class/pdf/originalpapers_2017_hirano_euro.pdf

  read this paper

• Development of a Shock-Wave Catheter Ablation System for Ventricular Tachyarrhythmias: Validation Study in Pigs In Vivo

  Basic Research Paper 3 (Validation Research 2)

  Morosawa S, Yamamoto H, Hirano M, Amamizu H, Uzuka H, Ohyama K, Hasebe Y, Nakano M, Fukuda K, Takayama K and Shimokawa H

  http://www.cardio.med.tohoku.ac.jp/class/pdf/01.pdf

  read this paper