Papers Review
Extracorporeal shock wave therapy for ischemic cardiovascular disorders.
Ito K, Fukumoto Y, Shimokawa H. H
doi: 10.2165/11592760-000000000-00000.PMID: 21846155
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Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.
Ito K, Fukumoto Y, Shimokawa H.
doi: 10.1620/tjem.219.1.PMID: 19713678
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Therapeutic Angiogenesis with Sound Waves
Shindo T, and Shimokawa H
http://www.cardio.med.tohoku.ac.jp/pdf/13_ra.20-00010.pdf
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Therapeutic potentials of sound waves in cardiovascular medicine: further important evidence
Shimokawa H
https://doi.org/10.1093/eurheartj/ehae253
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LIPUS: Dementia
Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia – Crucial roles of endothelial nitric oxide synthase
Dementia: Basic research paper
Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N and Shimokawa h
https://www.sciencedirect.com/science/article/pii/S1935861X18301591?via%3Dihub
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Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo.
Dementia: Basic research paper
Ichijo S, Shindo T, Eguchi K, Monma Y, Nakata T, Morisue Y, Kanai H, Osumi N, Yasuda S, Shimokawa H. https://www.nature.com/articles/s41598-021-84473-6
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Optimizing irradiation conditions for low‑intensity pulsed ultrasound to upregulate endothelial nitric oxide synthase Dementia: Basic research paper
Ouchi D, Mori S, Arakawa M, Shindo T, Shimokawa H, Yasuda S, Kanai H https://link.springer.com/article/10.1007/s10396-023-01382-z
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Optimal treatment conditions of the low-intensity pulsed ultrasound therapy for the treatment of Alzheimer’s disease -Applications from mice to humans- Dementia: Basic research paper
Shindo T, Eguchi K, Monma Y, Kanai H, Yasuda S, Shimokawa H. J Med Ultrasonics.
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A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial Dementia： clinical research paper
Shimokawa H, Shindo T, Ishiki A, Tomita N, Ichijyo S, Watanabe T, Nakata T, Eguchi K, Kikuchi Y, Shiroto T, Takahashi J, Yasuda S, Arai H https://www.jstage.jst.go.jp/article/tjem/258/3/258_2022.J078/_article
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Pivotal trial of low-intensity pulsed ultrasound therapy for early Alzheimer’s disease -Rationale and design- Dementia： clinical research paper 2
Shimokawa H, Akishita M, Ihara M, Teramukai S, Ishiki A, Nagai Y, Fukushima M. https://journals.sagepub.com/doi/10.1177/25424823241312108
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LIPUS: Angina
Low-Intensity Pulsed Ultrasound Induces Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Porcine Model of Chronic Myocardial Ischemia
Angina: Basic research paper
Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, Tuburaya R, Hasegawa H, Yasuda S, Kanai H and Shimokawa H
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104863
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Low-Intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Mouse Model of Acute Myocardial Infarction
Myocardial infarction: Basic research paper
Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, Kagaya Y, Hanawa K, Aizawa K, Shiroto T, Kasukabe S, Miyata S, Taki H, Hasegawa H, Kanai H and Shimokawa H
https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306477
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Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice
Pressure-loaded heart failure: Basic research paper
Ogata T, Ito K, Shindo T, Hatanaka K, Eguchi K, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Taki H, Kanai H and Shimokawa H
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185555
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Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo.
Watanabe T, Matsumoto Y, Nishimiya K, Shindo T, Amamizu H, Sugisawa J, Tsuchiya S, Sato K, Morosawa S, Ohyama K, Watanabe-Asaka T, Hayashi M, Kawai Y, Takahashi J, Yasuda S and Shimokawa H
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257175
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A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris
Severe Angina : Feasibility Clinical Trial
Shindo T,Ito K,Ogata T,Kurosawa R,Eguchi K,Kagaya Y,Hanawa K,Hasebe Y,Nishimiya K,Shiroto T,Takahashi J,Okumura Y,Noguchi T,Ozaki Y,Daida H,Hagiwara N,Masuyama T,Chikamori T,Fukumoto Y,Tsujita K,Kanai H,Yasuda S,Shimokawa H
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287714
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Low power extracorporeal shock wave treatment
Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo
Angina: Basic research paper
Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, Matsumoto Y, Kajihara N, Eto M, Matsuda T, Yasui h, Takeshita A, and Sunagawa K
https://www.ahajournals.org/doi/10.1161/01.CIR.0000148849.51177.97
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Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.
Angina: Basic research paper
Fukumoto Y, Ito A, Uwatoku T, Matoba T, Kishi T, Tanaka H, Takeshita A, Sunagawa K, Shimokawa H.
https://pubmed.ncbi.nlm.nih.gov/16374144/
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Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris
Angina: Clinical Research Paper 2: RCT Study
Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I and Shimokawa H
https://www.jstage.jst.go.jp/article/circj/74/3/74_CJ-09-1028/_article
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Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs
Myocardial infarction: Basic research paper 1
Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K and Shimokawa H
https://journals.lww.com/coronary-artery/Abstract/2007/08000/Extracorporeal_cardiac_shock_wave_therapy_improves.11.aspx
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Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia–reperfusion injury in pigs in vivo
Myocardial infarction: Basic research paper 2
Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi Gao Jun, Takeda M, Fukumoto Y, Yasuda S and Shimokawa H
https://journals.lww.com/coronary-artery/Abstract/2010/08000/Cardiac_shock_wave_therapy_ameliorates_left.9.aspx
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Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction:a first-in-human study
Myocardial infarction: clinical research paper
Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Shiroto T, Tsuburaya R, Kikuchi Y, Hao K, Nishimiya K, Shindo T, Ogata T, Kurosawa R, Eguchi K, Monma Y, Ichijo S, Hatanaka K, Miyata S and Shimokawa H.
https://journals.lww.com/coronary-artery/Abstract/2018/06000/Low_energy_cardiac_shockwave_therapy_to_suppress.4.aspx
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Extracorporeal Shock Wave Therapy Ameliorates Hindlimb Ischemia in Rabbits
Arteriosclerosis obliterans of the lower extremities: Clinical research paper
Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T and Shimokawa H
https://www.jstage.jst.go.jp/article/tjem/214/2/214_2_151/_article
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Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication
Arteriosclerosis obliterans of the lower extremities: Clinical research paper
Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato a, Shimokawa H and Satomi S
https://www.jstage.jst.go.jp/article/circj/76/6/76_CJ-11-1216/_article
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Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study
Collagen disease digital ulcers: clinical research paper
Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y and Harigae H
https://www.jstage.jst.go.jp/article/tjem/238/1/238_39/_article
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Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema
Lymphedema: Basic research paper
Serizawa F, Ito K, Matsubara M, Sato A, Shimokawa H and Satomi S
https://www.sciencedirect.com/science/article/pii/S1078588411001328?via%3Dihub
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Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury
Spinal cord injury: Basic research paper
Yamaya S, Ozawa H, Kanno H, Kishimoto K, Sekiguchi A, Tateda S, Yahata K, Ito K, Shimokawa H and Itoi E
https://thejns.org/view/journals/j-neurosurg/121/6/article-p1514.xml
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Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction.
Mechanism of action of low-power extracorporeal shock waves: Basic research paper
Hatanaka K, Ito K, Shindo T, Kagaya Y, Ogata T, Eguchi K, Kurosawa R and Shimokawa H
https://journals.physiology.org/doi/full/10.1152/ajpcell.00152.2016/
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Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats.
Kidney injury：Basic research paper
Yoshida M, Nakamichi T, Mori T, Ito K, Shimokawa H, Ito S.
https://pubmed.ncbi.nlm.nih.gov/30617840/
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Effectiveness and safety of low-energy shock wave therapy for digital ulcers associated with systemic sclerosis: a phase 3 pivotal clinical trial.
Collagen Disease: Clinical Research Papers
Ishii T, Kawaguchi Y, Ishikawa O, Takemori H, Takasawa N, Kobayashi H, Takahashi Y, Yasuoka H, Kodera T, Takai O, Nakaya I, Sato Y, Izumiyama T, Fujii H, Kamogawa Y, Shirota Y, Shirai T, Fujita Y, Saito S, Chiu SW, Yamaguchi T, Shimokawa H, Harigae H..
doi: 10.1093/mr/roae104. Online ahead of print.PMID: 39562303
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Low-energy shock wave therapy ameliorates ischemic-induced overactive bladder in a rat model.
The overactive bladder: a basic research paper
Kimura S, Kawamorita N, Kikuchi Y, Shindo T, Ishizuka Y, Satake Y, Sato T, Izumi H, Yamashita S, Yasuda S, Shimokawa H, Ito A.
doi: 10.1038/s41598-022-26292-x.PMID: 36536004
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Low-energy extracorporeal shock wave therapy promotes BDNF expression and improves functional recovery after spinal cord injury in rats.
Spinal Cord Injury: Basic Research Paperr
Matsuda M, Kanno H, Sugaya T, Yamaya S, Yahata K, Handa K, Shindo T, Shimokawa H, Ozawa H, Itoi E.
doi: 10.1016/j.expneurol.2020.113251. Epub 2020 Feb 19.PMID: 32087252
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Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function.
Hepatic Cirrhosis: Basic Research Paper
Ujiie N, Nakano T, Yamada M, Sato C, Nakanishi C, Fujishima F, Ito K, Shindo T, Shimokawa H, Kamei T
doi: 10.1038/s41598-020-58369-w.PMID: 32051434
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Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury.
Spinal Cord Injury: A Basic Research Paper
Yahata K, Kanno H, Ozawa H, Yamaya S, Tateda S, Ito K, Shimokawa H, Itoi E.
doi: 10.3171/2016.4.SPINE15923. Epub 2016 Jul 1.PMID: 27367940
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Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study.
Collagen Disease: Clinical Research Papers
Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y, Harigae H.
doi: 10.1620/tjem.238.39.PMID: 26686380
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Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase.
Skin Injuries: A Basic Study
Hayashi D, Kawakami K, Ito K, Ishii K, Tanno H, Imai Y, Kanno E, Maruyama R, Shimokawa H, Tachi M.
doi: 10.1111/j.1524-475X.2012.00851.x. Epub 2012 Oct 30.PMID: 23110611
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LIPUS: Heart failure
Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H, Shimokawa H. https://academic.oup.com/cardiovascres/article/117/5/1325/5873597
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Beneficial effects of low-intensity pulsed ultrasound therapy on right ventricular dysfunction in animal models. Nakata T, Shindo T, Ito K, Eguchi K, Monma Y, Ichijo S, Ryoke R, Satoh W, Kumasaka K, Satoh H, Kurosawa R, Satoh K, Kawashima R, Miura M, Kanai H, Yasuda S, Shimokawa H. https://www.sciencedirect.com/science/article/pii/S2452302X22003382
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Shock wave ablation catheter
Development of a Novel Shock WaveCatheter Ablation System -The First Feasibility Study in Pigs
Basic Research Paper 1 (System Development)
Hasebe Y, Yamamoto H, Fukuda K, Nishimiya K, Hanawa K, Shindo T, Kondo M, Nakano M, Wakayama Y, Takayama K and Shimokawa H
http://www.cardio.med.tohoku.ac.jp/class/pdf/originalpapers_2015_03.pdf
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Development of a novel shock wave catheter ablation system—A validation study in pigs in vivo
Basic Research Paper 2 (Validation Research 1)
Hirano M, Yamamoto H, Hasebe Y, Fukuda K, Morosawa S, Amamizu H, Ohyama K, Uzuka H, Takayama K and Shimokawa H
http://www.cardio.med.tohoku.ac.jp/class/pdf/originalpapers_2017_hirano_euro.pdf
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Development of a Shock-Wave Catheter Ablation System for Ventricular Tachyarrhythmias: Validation Study in Pigs In Vivo
Basic Research Paper 3 (Validation Research 2)
Morosawa S, Yamamoto H, Hirano M, Amamizu H, Uzuka H, Ohyama K, Hasebe Y, Nakano M, Fukuda K, Takayama K and Shimokawa H
http://www.cardio.med.tohoku.ac.jp/class/pdf/01.pdf
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